Last data update: May 13, 2024. (Total: 46773 publications since 2009)
Records 1-3 (of 3 Records) |
Query Trace: Riemersma KK[original query] |
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Shedding of Infectious SARS-CoV-2 Despite Vaccination (preprint)
Riemersma KK , Haddock LA , Wilson NA , Minor N , Eickhoff J , Grogan BE , Kita-Yarbro A , Halfmann PJ , Segaloff HE , Kocharian A , Florek KR , Westergaard R , Bateman A , Jeppson GE , Kawaoka Y , O'Connor DH , Friedrich TC , Grande KM . medRxiv 2021 31 The SARS-CoV-2 Delta Variant of Concern is highly transmissible and contains mutations that confer partial immune escape. The emergence of Delta in North America caused the first surge in COVID-19 cases after SARSCoV-2 vaccines became widely available. To determine whether individuals infected despite vaccination might be capable of transmitting SARS-CoV-2, we compared RT-PCR cycle threshold (Ct) data from 20,431 test-positive anterior nasal swab specimens from fully vaccinated (n = 9,347) or unvaccinated (n=11,084) individuals tested at a single commercial laboratory during the interval 28 June - 1 December 2021 when Delta variants were predominant. We observed no significant effect of vaccine status alone on Ct value, nor when controlling for vaccine product or sex. Testing a subset of low-Ct (<25) samples, we detected infectious virus at similar rates, and at similar titers, in specimens from vaccinated and unvaccinated individuals. These data indicate that vaccinated individuals infected with Delta variants are capable of shedding infectious SARS-CoV-2 and could play a role in spreading COVID-19. Copyright The copyright holder for this preprint is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license. |
Shedding of infectious SARS-CoV-2 despite vaccination.
Riemersma KK , Haddock LA3rd , Wilson NA , Minor N , Eickhoff J , Grogan BE , Kita-Yarbro A , Halfmann PJ , Segaloff HE , Kocharian A , Florek KR , Westergaard R , Bateman A , Jeppson GE , Kawaoka Y , O'Connor DH , Friedrich TC , Grande KM . PLoS Pathog 2022 18 (9) e1010876 The SARS-CoV-2 Delta Variant of Concern is highly transmissible and contains mutations that confer partial immune escape. The emergence of Delta in North America caused the first surge in COVID-19 cases after SARS-CoV-2 vaccines became widely available. To determine whether individuals infected despite vaccination might be capable of transmitting SARS-CoV-2, we compared RT-PCR cycle threshold (Ct) data from 20,431 test-positive anterior nasal swab specimens from fully vaccinated (n = 9,347) or unvaccinated (n = 11,084) individuals tested at a single commercial laboratory during the interval 28 June- 1 December 2021 when Delta variants were predominant. We observed no significant effect of vaccine status alone on Ct value, nor when controlling for vaccine product or sex. Testing a subset of low-Ct (<25) samples, we detected infectious virus at similar rates, and at similar titers, in specimens from vaccinated and unvaccinated individuals. These data indicate that vaccinated individuals infected with Delta variants are capable of shedding infectious SARS-CoV-2 and could play a role in spreading COVID-19. |
Heartland virus neutralizing antibodies in vertebrate wildlife, United States, 2009-2014
Riemersma KK , Komar N . Emerg Infect Dis 2015 21 (10) 1830-1833 Since its discovery in 2009, the tickborne Heartland virus (HRTV) has caused human illness in Missouri, Oklahoma, and Tennessee USA. To better assess the geographic distribution of HRTV, we used wildlife serology as an indicator. This retrospective evaluation determined that HRTV is widespread within the central and eastern United States. |
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